The DOCK11 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DOCK11. This antibody recognizes Human, Mouse, and Rat antigen. The DOCK11 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.
Subunit Structure: Interacts with CDC42.
Similarity: The DHR-2 domain is necessary for the GEF activity. Belongs to the DOCK family